INTRAOCULAR PRESSURE CHANGES AFTER INTRAVITREAL BEVACIZUMAB INJECTION ALONE OR COMBINATION OF BEVACIZUMAB AND TRIAMCINOLONE ACETONIDE

Nour Yasser Barakat*, Yusuf Suleiman and Kahtan Jalloul

ABSTRACT

This conducted study was to evaluate intraocular pressure changes after intravitreal injection of Bevacizumab alone or in combination with Triamcinolone Acetonide. A prospective study included 63 eyes from the ophthalmology department at Tishreen University Hospital who had vascular retinal diseases from 1st January 2019 to 1st January 2020. Patients were divided into two groups according to the indication of injection. The first group was injected with bevacizumab (B) (2.5mg / 0.1) ml and the second group was injected with the combination of (B+TA) Triamcinolone Acetonide (2mg / 0.05ml) with bevacizuma of (1.25mg/ 0.05ml) .Intraocular pressure was monitored on the Goldman applanation tonometry and values were recorded as follows: before the injection, the second day, a week, a month and after three months of injection. The results showed that the mean values of the intraocular pressure increased from the second day of injection in (B) and (B + TA). The means of the IOP values before injection were(13.34-13.31 mmHg) respectively, and increased to their maximum values (17.81-17.31 mmHg) in both groups after a week of injection, then they began to decrease after a month and three months later to(17.34- 17.06mmHg) and (17.6-16.75mmHg) respectively, but they remained higher than they were before the injection. The number of injections had no effect on intraocular pressure. Our study conclude that intravitreal injections with both bevacizumab alone or in combination with triamcinolone acetonide resulted in an increase in intraocular pressure, and the differences in pressure values were statistically significant within the same group during the studied period but were not statistically significant between the two groups, and the number of injections had no effect on intraocular pressure.

Keywords: Bevacizumab, Triamcinolone Acetonide, Intraocular Pressure.