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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Asif Ali, Mohammed Ali*, Showkat Rassol Mir, Md. Kamaruz Zaman and Shahnaz Sultana


Streptomyces coelicolor produces various type of compounds by means of specialized biosynthetic pathways. This paper reports the isolation and identification of chemical constituents found in a fermentation broth of S. coelicolor. A methanol extract of the cells of S. coelicolor was chromatographed over a silica gel column. The column was eluted with various solvent mixtures of increasing polarity to isolate the chemical constituents. Elution of the column with petroleum ether - chloroform (1:1) yielded a new 2,3-dihydro-1-benzopyran-4-one identified as 2α-methyl-8-hydroxy-4-chromanone (1). Elution of the column with chloroform gave yellow crystals of a new alkylated β-naphthol carboxylic acid characterized as 1-(2'-pentanyl-1'-aldehyde)-2-hydroxy-8-naphthoic acid (2). Lawsonyl-1,3-dimethyl-2α-(10,14-dimethyl nonan-7β-olyl)cyclohexan-1-oate (3), a new diterpenic ester with lawsone, was isolated when the column was eluted with chloroform-methanol (19:1) mixture. Elution of the column with chloroform-methanol (9:1) furnished red crystals of 3-[1-(2'-hexan-1'-al-4'-one)-2-hydroxy-8-naphthoic acid]-3''-[1''-(2'''-hexan-1'''-al)-2''-hydroxy-8''-naphthoic acid]-hydroxy methine (4), a new dinaphthol-1, 1''-dihexanal-8, 8''-dioic acid carbinol derivative. The leaves of Oxalis debilis Kunth (Oxalidaceae) possess analgesic, anodyne, antiscorbutic, astringent, diuretic, emmenagogue, expectorant and stomachic properties and are used to treat earache, fevers and to quench the thirst. Phytochemical investigation of the leaves of O. debilis furnished a known phytosterol, stigmasterol (5) and a higher aliphatic alcohols identified as 1-heptatriacontanol (6). The structures of these natural products were elucidated on the basis of spectral data analysis and chemical reactions.

Keywords: Streptomyces coelicolor, spore germination, Oxalis debilis leaves, chemical constituents, isolation, identification.

[Full Text Article]




    AUGUST Issue has been successfully launched on 1 August 2022.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database