VALIDATED AUC METHOD FOR THE SPECTROPHOTOMETRIC ESTIMATION ABIRATERONE ACETATE IN BULK AND TABLET DOSAGE FORM
Manojkumar S., Pramila T.* and Poojashree P.
A new simple Area under curve spectroscopic method was developed and validated for the estimation of
Abiraterone acetate in bulk and pharmaceutical dosage forms and Area under curve was measured at 248-258nm in
Methanol. The linearity was found to be in the concentration range of 2-10 μg/ml and the correlation coefficient
was found to be 0.9998 and it has showed good linearity, reproducibility, precision in this concentration range. The
regression equation was found to be Y=0.0282X+0.0019. The % recovery values were found to be within the 99-
100% and showed that the method was accurate. The LOD and LOQ were found to be 0.1278 and 0.3835 μg/ml
respectively. The % RSD values were less than 2. The present method is accomplishing the validation parameters
according to ICH guidelines. The developed method was successfully applied for the quantitative estimation of
Abiraterone Acetate in bulk and pharmaceutical dosage forms.
Keywords: Abiraterone acetate, Area under curve, Spectroscopy, Methanol, Linearity, Ruggedness, Precision, Accuracy.
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