NOVEL FORMULATION DEVELOPMENT AND OPTIMIZATION OF MEDICATED CHEWING GUM OF ONDANSETRON HYDROCHLORIDE

Atul A. Baravkar*, Amar G. Zalte, V. S. Gulecha and R. R. Jain

ABSTRACT

Medicated chewing gum is considered as vehicle or drug delivery system to administer active principles that can improve health and nutrition. It is a completely unique drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. The aim of present study was to prepare chewing gum of Ondansetron hydrochloride for the treatment of nausea and vomiting. Novel chewing formulation was prepared by using gum base as a base, Aerosil as a release modifier, sucrose as a filler and buffer. The effect of concentration of ingredients was studied. The dissolution studies showed that optimum amount of gum base shows superior results. Maximum peak plasma concentration is reached after approximately 1 h. This model is selected for the study in order to overcome the hepatic first-pass effect and there by possible reduction in the dose. To mask the bitter taste of Ondansetron hydrochloride, sodium saccharin was used as sugar base. Ondansetron hydrochloride has higher salivary (artificial saliva) solubility, less side effects and has short duration of action of about 3 hr; these factors make Ondansetron Hydrochloride a suitable candidate for formulation of medicated chewing gum used to treat nausea and vomiting.

Keywords: Medicated Chewing Gum, Ondansetron, Nausea, Vomiting etc.