PRONIOSOMAL GEL FOR TRANSDERMAL DELIVERY OF REPAGLINIDE: OPTIMIZATION USING 2 X 2 FACTORIAL DESIGN
Satheesh A. P.*, Parthiban S. and Senthilkumar G. P.
The aim of the present study is to formulate and evaluate Proniosomal gel formulations as transdermal delivery systems of Repaglinide to improve its therapeutic effect in a controlled manner. A 2x2 factorial design have been applied for optimization, by varying surfactant and soyalecithin concentration. All the formulations were evaluated for various parameters such as vesicle size analysis, surface morphology, zeta potential, pH, stability studies. The result shows that the Tween 60 (T1F3) have better Entrapment efficiency (95.85±0.8) and also high % drug content (94.67±0.5) compare to Tween40, it is evident that Tween 60 is better suitable surfactant to enhance the bioavailability and better therapeutic effect of Repaglinide loaded Proniosomal gel through transdermal drug delivery system.
Keywords: Proniosomal gel of Repaglinide, Transdermal delivery, Antidiabetic, 2 X 2 Factorial design.
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