EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PRONIOSOMAL GEL FOR TRANSDERMAL DELIVERY OF REPAGLINIDE: OPTIMIZATION USING 2 X 2 FACTORIAL DESIGN

Satheesh A. P.*, Parthiban S. and Senthilkumar G. P.

ABSTRACT

The aim of the present study is to formulate and evaluate Proniosomal gel formulations as transdermal delivery systems of Repaglinide to improve its therapeutic effect in a controlled manner. A 2x2 factorial design have been applied for optimization, by varying surfactant and soyalecithin concentration. All the formulations were evaluated for various parameters such as vesicle size analysis, surface morphology, zeta potential, pH, stability studies. The result shows that the Tween 60 (T1F3) have better Entrapment efficiency (95.85±0.8) and also high % drug content (94.67±0.5) compare to Tween40, it is evident that Tween 60 is better suitable surfactant to enhance the bioavailability and better therapeutic effect of Repaglinide loaded Proniosomal gel through transdermal drug delivery system.

Keywords: Proniosomal gel of Repaglinide, Transdermal delivery, Antidiabetic, 2 X 2 Factorial design.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing