EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF IPN MICROSPHERE OF INDOMETHACIN

Jyoti More*, Archana Barhate, Sagar D. Shinde, Swati B. Kavade and Pradnya Salunkhe

ABSTRACT

Interpenetrating polymer network (IPN) is one of the valuable novel biomaterials. An IPN is a combination of at least two polymers and IPN can produce synergistic effect by sharing the properties of both the polymer. IPN microspheres of Indomethacin were prepared using emulsion cross-linking method. IPN Microspheres were prepared using sodium alginate and polyvinyl alcohol (PVA) in the ratio of 1:2, 1:3 and 1:4 using glutaraldehyde as a cross linking agent. Compatibility studies suggested no physicochemical interaction between the drug and the polymers. Microspheres were evaluated for particle size, entrapment efficiency, percentage yield, and equilibrium water up take. By increasing the ratio of poly vinyl alcohol, a slight increase in percent entrapment efficiency was observed. The effect of cross-linking on percent entrapment efficiency was significant. Increase in the amount of cross-linker in the matrices; significantly decrease the percent equilibrium water uptake. In-vitro dissolution study showed 90-98 % drug release at the end of 24 h.

Keywords: Indomethacin, interpenetrating polymer network, sodium alginate, polyvinyl alcohol.

[Full Text Article] [Download Certificate]