A REVIEW ON SOLID LIPID NANOPARTICLES- A NEW MODEL APPROAX FOR EFFECETIVE DRUG DELIVERY

*Puvvala Syamala Rani and Dr. P. Veera Lakshmi

ABSTRACT

Most of the active pharmaceutical ingredients (APIs) under development are poorly water-soluble and have poor bioavailability. Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems. Solid lipid nanoparticles were developed in early 1990s as an alternate to other traditional colloidal carriers like liposomes polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. It is identical to an oil-in-water emulsion for parenteral nutrition still, the liquid lipid (oil) of the emulsion has been replaced by a solid fat, i.e, yielding solid lipid Nanoparticles. Different production methods that are suitable for large scale production and applications of stable lipid nanoparticles described. In this review article we have focused on different development techniques those are High pressure homogenization, Ultra sonication method, Solvent injection technique, Solvent emulsification- evaporation method, Micro emulsion based method, Solvent evaporation- diffusion method, Spray drying, double emulsion based method. We have discussed appropriate analytical techniques for the evaluation of SLN like photon correlation spectroscopy, measurement of particle size and zeta potential, Invitro drug release, Atomic force, Electron microscopy, Differential scanning calorimetry, determination of incorporated drug (loading efficiency and entrapment efficiency).

Keywords: Solid lipid nanoparticles, Liposomes, Solvent emulsification- evaporation method, Reticulo endoplasmic system.