EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

RHO KINASE INHIBITORS: THE MULTIFACETED DRUG IN OPHTHALMOLOGY

*Prathama Sarkar, Amit Mehtani, Harish C. Gandhi, Jatinder Singh Bhalla, Satish Tapariya and Pooja Nikas

ABSTRACT

The evolution of Rho Kinase (ROCK) inhibitors as therapeutic agents in ophthalmology has been seen as a positive approach for containing and managing various diseases. In this review, a detailed and comprehensive overview of the published literature on the use of Rho kinase inhibitors for various ophthalmological purposes has been provid-ed by us. A systematic review of many databases has been performed to identify ample literature on ROCK inhibi-tors. This research found strong evidence establishing that inhibition of Rho kinase markedly decreases IOP, in-creases healing of the corneal endothelium, stalls the progression of diabetic retinopathy, has a significant role in axial myopia and various other Vitreo-retinal diseases. It is quite evident that Rho kinase inhibitors have the ability to be another effective therapeutic alternative for a variety of chronic diseases in ophthalmology.

Keywords: Rho kinase, Rho kinase inhibitors, ROCK, Y-27632, Ripasudil (K-115), Netarsudil.

[Full Text Article] [Download Certificate]