RHO KINASE INHIBITORS: THE MULTIFACETED DRUG IN OPHTHALMOLOGY
*Prathama Sarkar, Amit Mehtani, Harish C. Gandhi, Jatinder Singh Bhalla, Satish Tapariya and Pooja Nikas
The evolution of Rho Kinase (ROCK) inhibitors as therapeutic agents in ophthalmology has been seen as a positive approach for containing and managing various diseases. In this review, a detailed and comprehensive overview of the published literature on the use of Rho kinase inhibitors for various ophthalmological purposes has been provid-ed by us. A systematic review of many databases has been performed to identify ample literature on ROCK inhibi-tors. This research found strong evidence establishing that inhibition of Rho kinase markedly decreases IOP, in-creases healing of the corneal endothelium, stalls the progression of diabetic retinopathy, has a significant role in axial myopia and various other Vitreo-retinal diseases. It is quite evident that Rho kinase inhibitors have the ability to be another effective therapeutic alternative for a variety of chronic diseases in ophthalmology.
Keywords: Rho kinase, Rho kinase inhibitors, ROCK, Y-27632, Ripasudil (K-115), Netarsudil.
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