SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS BY SOLID DISPERSION TECHNIQUES: A REVIEW

Shubhangi Pawar*, Mithun Maniyar and Shubhada Pawar

ABSTRACT

The solubility enhancement of drug remains one of the most challenging aspects in the formulation development. protein solubility of drug or active ingredients is one of the important parameter to gain desired concentration of drug in the systemic circulation to achieve expected pharmacological response. Solid dispersion is one of the most promising approach for solubility enhancement. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to a formulation scientists due to their solubility criteria. The focus of this review article on the method of preparation, carrier, solvent use, it also elaborates various factors, advantages, disadvantages, and the application of the solid dispersion.

Keywords: Solid dispersions, solubility, carrier, method of preparation.