EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTS OF GARLIC (ALLIUM SATIVUM L.)-SUPPLEMENTED DIETS ON PLASMA CGMP, NITRIC OXIDE LEVELS AND BLOOD PRESSURE IN NORMOTENSIVE WISTAR RATS

Ajayi Oluwadamilare Oluwaseun*, Ajayi Olubunmi Bolanle, Ayodele Oyinlola Roseline, Kayode Adekunle Blessing, Adedipe Praise Oreoluwa, and Akinola Hafsah Olajumoke

ABSTRACT

This short study assessed the effects of garlic on blood pressure vis-à-vis plasma cGMP and Nitric oxide (NO) levels in normotensive rats fed garlic-based diets for 7 days. The animals used for this study were randomly sorted into three (3) groups (n=4). Group 1: normotensive rats (fed basal diet without garlic powder); Group 2: normotensive rats fed 10% garlic-based diet; Group 3: normotensive rats fed 20% garlic-based diet. After experimental feeding for 7 days, plasma cGMP and NO levels were found to have increased, although insignificantly (p ˂ 0.05), in the rats fed 10% and 20% garlic-based diets when compared with rats fed basal diet. Also, systolic and diastolic blood pressure values were found to be significantly increased (p ˂ 0.05) in normotensive rats fed 10% garlic-based diet when compared with rats fed basal diet. However, it was observed that systolic blood pressure was significantly decreased (p ˂ 0.05) in rats fed 20% garlic-based diets, when compared with normotensive rats fed basal diet and normotensive rats fed 10%. Also, diastolic blood pressure was insignificantly increased (p ˂ 0.05) when compared with normotensive rats fed basal diet, but significantly reduced when compared with normotensive rats fed 10% garlic-based diet. These findings may suggest that prolonged consumption of garlic by normotensive subjects especially in high quantities, may affect their blood pressure readings.

Keywords: Garlic, Hypertension, Nitric oxide, Allium sativum.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing