( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Adjene Josiah Obaghwarhievwo, Avbunudiogba John Afokoghene and *Odigie Mike Osagie


This study investigated the changes in female reproductive hormones (hormonal profile) and relative ovarian weights due to administration of aqueous extract of bitter kola (Garcinia kola) on female Wistar rats. Thirty (30) adult wistar rats of between 150 g – 200 g were procured, acclimatized and randomly selected into five (5) groups of six (6) rats each. Group A (Control) received standard rat diet and water ad libitum, while group B rats were fed with 100 mg/kg body weight of aqueous extract of Garcinia kola. Groups C, D and E received 200 mg/kg, 300 mg/kg and 400 mg/kg body weight of aqueous extracts of Garcinia kola respectively. After twenty-one (21) days of administration of test substance, the rats were sacrificed via cervical dislocation and blood samples collected and assayed for serum hormonal levels [Follicle Stimulating Hormone - FSH, Luteinizing Hormone - LH, Oestrogen and Progesterone]. Study also determined the comparative changes in body / ovarian weights of animals before and after administration of test substance, following which the Statistical Package for Social Sciences (SPSS, version 20) was used to conduct statistical test (student t-test) on obtained data; at p-values ≤ 0.05 as significant level, study observed a significant increase in body with increasing dose of G. kola administration. G. kola also caused an increase in serum hormonal levels of female wistar rats, promoting oogenesis and maturation of the ovarian follicle. Further studies aimed at corroborating these results should be carried out.

Keywords: Gacinia kola, FSH, LH, Estrogen, Progesterone.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database