EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPAIRMENT OF ENDOTHELIUM-DEPENDENT VASODILATATION AND HYPERHOMOCYSTEINEMIA: PROGNOSTIC IMPLICATIONS OF ENDOTHELIAL DYSFUNCTION AFTER CAROTID ENDARTERECTOMY

Umarov B.Y., Abdurakhmanov M.M. and Abdurakhmanov Z.M.*

ABSTRACT

Objective: To evaluate and compare pre- and post-patch (p-CEA) and eversion carotid endarterectomy (e-CEA) markers of endothelial dysfunction in order to improve the diagnosis, surgical results of patients with carotid artery disease. Materials and methods: From October 2014 to October 2019, we examined 87 patients who underwent p-CEA (n=38) and p-CEA (n=49) at our medical center. Preoperative flow-mediated dilation (FMD) of brachial artery and pre- and immediate postoperative homocysteine level were compared between groups. Results: In the preoperative period, the impairment of endothelium-dependent vasodilatation and level of homocysteine of a higher than >10 mmol/l appeared to be experienced in 77 (88,5%) and 82 (94,2%) patients, respectively. In patients of the p-CEA group, the average FMD of the brachial artery was 5,67±1,54%, and 5,51±1,64% which was significantly lower than those of the e-CEA of 6,85±1,70% and 6,13±1,75% at 30 and 60 seconds post-cuff release, respectively (p<0,05). On day 6 after the operation, the homocysteine concentration increased compared to the preoperative level from 15,80±4,32 to 18,4±4,2 μmol/l (p<0,05) in the p-CEA group. In contrast, a preoperative homocysteine level of 13,10±3,15 μmol/l reached up to 14,2±5,6 μmol/l in the e-CEA group without significant difference (p>0,05). Conclusion: In the preoperative period, the flow-mediated dilation test showed better result in favor of e-CEA when compared to p-CEA. In the postoperative period, the growth of the homocysteine level was observed in the p-CEA group in contrast to e-CEA. Further study will be required to detect the precise association of hyperhomocysteinemia with suboptimal hemodynamic parameters of p-CEA.

Keywords: endothelial dysfunction, carotid endarterectomy, flow-mediated dilation, hyperhomocysteinemia.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing