EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

EFFECTS OF GRADED DOSES OF RESVERATROL ON RECTAL TEMPERATURE AND BODY WEIGHT OF TRYPANOSOMA BRUCEI INFECTED MALE DOGS TREATED WITH DIMINAZENE ACETURATE

*Odo Rita Ifeoma, Asuzu Isaac Uzoma and Ezema Chuka

ABSTRACT

The study investigated the influence of graded doses of resveratrol on trypanosomosis induced fever and weight loss in T. brucei infected male dogs treated with diminazene aceturate (DA). Thirty male dogs were used for the study and were assigned into six groups (n=5). Group A was infected with T. brucei, not treated with (DA) and not supplemented with resveratrol. Group B was presupplemented with resveratrol (50 mg/kg) for 7 days, Infected with T. brucei and treated with DA (7 mg/kg). Group C was presupplemented with resveratrol (100 mg/kg) for 7 days, infected with T. brucei and treated with DA (7 mg/kg). Group D was presupplemented with resveratrol (200 mg/kg) for 7 days, infected with T. brucei and treated with DA (7 mg/kg). Groups B, C and D were postsupplemented with 50, 100 and 200 mg/kg of resveratrol for 14 days respectively. Group E was infected with T. brucei and treated with DA (7 mg/kg). Group F was the normal control. There were significant decreases (p < 0.05) in the parasitaemia level and rectal temperature of dogs supplemented with 100 mg/kg of resveratrol when compared to those supplemented with 50 mg/kg, 200 mg/kg and the infected unsupplemented group. There was a significant increase (p < 0.05) in weight gain of dogs supplemented with 100 mg/kg of resveratrol when compared to those supplemented with 50 mg/kg, 200 mg/kg, treated with DA alone and the infected untreated group. In conclusion, 100 mg/kg of resveratrol produced optimum activity in reducing fever and increasing body weight in DA treated Trypanosoma infected male dogs.

Keywords: Trypanosomosis, resveratrol, diminazene aceturate, fever, body weight.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing