EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF RENAL FUNCTION PARAMETERS AND LIPID PEROXIDATION IN SOLID WASTE WORKERS IN YENAGOA, NIGERIA

Onitsha Enebrayi Nelson*, Okutu Jackson Borobuebi, Ofor Igri Bassey

ABSTRACT

Environmental contamination due to solid waste disposal is a global issue that portends serious health problems to humans. This present study is designed to evaluate some renal function parameters and lipid peroxidation in solid waste workers in Yenagoa, Nigeria. Methods: A total of ninety (90) apparently healthy male recruits within the age range of twenty (20) and forty (40) years were used in this study. Sixty (60) recruits were solid waste workers, and thirty (30) served as control. Sera were collected, prepared and stored at -20oC prior to analysis which employed Ion Selective Electrode and Spectrophotometry. The result showed statistically significant (P<0.05) increase in the mean±SD values of creatinine (113.25±19.94), urea (4.03±0.89) and uric acid (178.35±4.74) in the tests when compared with controls (89.43±15.25, 2.51±1.42 and 158.5±2.95) respectively. There were slight decreases in the sera concentrations of sodium (135.07±9.35), potassium (3.85±0.42) and chloride (96.90±15.66) which nonetheless, were not statistically significant (p>0.05) in the tests when compared with controls (136.74±12.03, 4.08±0.47, 99.85±5.01 and 4.03±0.89) respectively. Lipid peroxidation product, Malondialdehyde (7.37±1.57) was significantly (0.001) elevated in the tests when compared with controls (5.88±0.42). In recruitts with duration of exposure ≥2years, sodium was significantly decreased compared with <2years of exposure. Creatinine, uric acid and malondiadehyde were significantly (p<0.05) increased among recruitts with ≥2years duration of exposure compared with <2years of exposure. Solid wastes have a negative effect on the renal function and lipid peroxidation which is dependent on the duration of exposure.

Keywords: Solid Wastes; Renal function parameters; Lipid peroxidation.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing