EVALUATION OF RENAL FUNCTION PARAMETERS AND LIPID PEROXIDATION IN SOLID WASTE WORKERS IN YENAGOA, NIGERIA
Onitsha Enebrayi Nelson*, Okutu Jackson Borobuebi, Ofor Igri Bassey
Environmental contamination due to solid waste disposal is a global issue that portends serious health problems to humans. This present study is designed to evaluate some renal function parameters and lipid peroxidation in solid waste workers in Yenagoa, Nigeria. Methods: A total of ninety (90) apparently healthy male recruits within the age range of twenty (20) and forty (40) years were used in this study. Sixty (60) recruits were solid waste workers, and thirty (30) served as control. Sera were collected, prepared and stored at -20oC prior to analysis which employed Ion Selective Electrode and Spectrophotometry. The result showed statistically significant (P<0.05) increase in the mean±SD values of creatinine (113.25±19.94), urea (4.03±0.89) and uric acid (178.35±4.74) in the tests when compared with controls (89.43±15.25, 2.51±1.42 and 158.5±2.95) respectively. There were slight decreases in the sera concentrations of sodium (135.07±9.35), potassium (3.85±0.42) and chloride (96.90±15.66) which nonetheless, were not statistically significant (p>0.05) in the tests when compared with controls (136.74±12.03, 4.08±0.47, 99.85±5.01 and 4.03±0.89) respectively. Lipid peroxidation product, Malondialdehyde (7.37±1.57) was significantly (0.001) elevated in the tests when compared with controls (5.88±0.42). In recruitts with duration of exposure ≥2years, sodium was significantly decreased compared with <2years of exposure. Creatinine, uric acid and malondiadehyde were significantly (p<0.05) increased among recruitts with ≥2years duration of exposure compared with <2years of exposure. Solid wastes have a negative effect on the renal function and lipid peroxidation which is dependent on the duration of exposure.
Keywords: Solid Wastes; Renal function parameters; Lipid peroxidation.
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