EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

APPROACHES TO IMMUNODIAGNOSIS OF VIRUS-ASSOCIATED NON-HODGKINIAN LYMPHOS

*Tillyashaikhov M. N. and Abdiganiyeva S. R.

ABSTRACT

The aim of the study was to study the immunodiagnostic basic cellular values of the immune system that characterize adaptive immunity in patients with non-Hodgkin's lymphomas. Due to the relevance of the presence of infection of patients with the Epstein-barr virus, patients were divided into groups of infected patients and without infection. In this regard, the main markers of adaptive immunity were studied against the background of infection and without infection. The analysis showed that pronounced changes in the state of cellular adaptive immunity were detected in a significant suppression of CD3 + T-lymphocytes, CD3 + CD4 + T-helpers / inducers and an immunoregulatory index against the background of an increase in T-cytotoxic lymphocytes, natural killer cells and B-lymphocytes. It is important to note that markers of lymphocyte activation turned out to be elevated, the study of which is important in immunodiagnostics for lymphomas. These markers characterize the prognosis of relapse of the disease or vice versa, their more favorable course. Moreover, immunological markers of lymphocytes were most indicative in the presence of Epstein-Barr virus infection. There is also a pronounced imbalance of humoral immunity values. The circulating immune complexes and immunoglobulins were increased, while the highest increase in small CIC was observed in groups of patients before chemotherapy for infected EBV.

Keywords: immunodiagnostics, adaptive immunity, immunocompetent cells, non-Hodgkin lymphoma, viruses.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )