APPROACHES TO IMMUNODIAGNOSIS OF VIRUS-ASSOCIATED NON-HODGKINIAN LYMPHOS

*Tillyashaikhov M. N. and Abdiganiyeva S. R.

ABSTRACT

The aim of the study was to study the immunodiagnostic basic cellular values of the immune system that characterize adaptive immunity in patients with non-Hodgkin's lymphomas. Due to the relevance of the presence of infection of patients with the Epstein-barr virus, patients were divided into groups of infected patients and without infection. In this regard, the main markers of adaptive immunity were studied against the background of infection and without infection. The analysis showed that pronounced changes in the state of cellular adaptive immunity were detected in a significant suppression of CD3 + T-lymphocytes, CD3 + CD4 + T-helpers / inducers and an immunoregulatory index against the background of an increase in T-cytotoxic lymphocytes, natural killer cells and B-lymphocytes. It is important to note that markers of lymphocyte activation turned out to be elevated, the study of which is important in immunodiagnostics for lymphomas. These markers characterize the prognosis of relapse of the disease or vice versa, their more favorable course. Moreover, immunological markers of lymphocytes were most indicative in the presence of Epstein-Barr virus infection. There is also a pronounced imbalance of humoral immunity values. The circulating immune complexes and immunoglobulins were increased, while the highest increase in small CIC was observed in groups of patients before chemotherapy for infected EBV.

Keywords: immunodiagnostics, adaptive immunity, immunocompetent cells, non-Hodgkin lymphoma, viruses.