PROTEIN STRUCTURE PREDICTION AND PROTEIN STRUCTURE COMPARISON BY ALIGNMENT OF SARS-COV-2 SPIKE GLYCOPROTEIN AND ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) FROM DIFFERENT ORGANISM'S HOST

Prasad Choukidar, *Sumedh Choukidar and Dr. Sanjay Harke

ABSTRACT

Coronavirus disease (covid-19) is an infectious Disease caused by severe acute respiratory syndrome (SARS-cov-2) previously known as "ncov-19" has been associated with The recent epidemic of acute respiratory distress syndrome. the first cases were seen in Wuhan, China in December 2019 before spreading Globally recent studies have suggested that Angiotensin-converting enzyme 2 (ACE2) is more likely to be the cell receptor through which the SARS-COV-2 virus invades the host cell using the spike glycoprotein. in the present work we make the protein Structure alignment and calculates the RMSD score in between the SARS-COV-2 spike glycoprotein and ACE2 receptor from Different organism's host. To make the protein Structure alignment and the calculation of RMSD score we use the Pymol Structure visualization tool.

Keywords: SARS-COV-2, Structure Prediction, Structure Alignment.