FORMULATION AND EVALUATION OF GELATIN NANOPARTICLES OF ANTI-PSYCHOTIC DRUGS

Asha Rani M.*, Dr. Lakshmi CSR and Dr. Nargund lVG

ABSTRACT

Antipsychotic drugs loaded gelatin nanoparticles (G-NPs) were prepared by desolvation method using acetone as solvent and glutaraldehyde as cross linking agent. The prepared gelatin nanoparticles were characterized for particle size, shape, zeta potential and encapsulation efficiency. Different ratios of drug:polymer (1:1, 1:2, 1:3), different concentrations of acetone (10ml,20ml,30ml) as solvent were used. The particle size distribution of prepared gelatin nanoparticles ranged from 105.0±0.2nm to 256.9±0.5nm. The zeta potential of the prepared gelatin nanoparticles ranged from 9.1±2.0mV to 14.8±0.4mV. The encapsulation efficiency of drug loaded G-NPs was ranged from 42±0.6% to 79±2.4%. By increasing the concentration of Gelatin (G) decrease in the particle size, increase in the zeta potential and encapsulation efficiency were observed and by further increasing the concentration of gelatin, increase in the particle size, decrease in the zeta potential and encapsulation efficiency were observed. Among all the formulations drug:polymer ratio of 1:2 with 20ml acetone as solvent and 100μl of 4% glutaraldehyde as cross linking agent showed better results for the treatment of psychotic disorders.

Keywords: Nanoparticles, Antipsychotics, Schizophrenia, Gelatin, Desolvation.