EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

MOLECULAR DOCKING, SYNTHESIS, CHARACTERISATION AND IN VITRO ANTI-FUNGAL EVALUATION OF SOME NOVEL DERIVATIVES OF 6-CHLORO-9-(3-CHLORO-4-FLUOROPHENYL)-9H-PURIN-2-AMINE

Vijaya Kumar P.*, Yadati Narasimha Spoorthy and L. K. Rvindranath

ABSTRACT

4, 6-dichloropyrimidine-2,5-diamine hydro chloride on treatment with 3-chloro-4-fluoro aniline in presence of alcohol results in the formation of 6-chloro-N4-(3-chloro-4-fluorophenyl) pyrimidine-2, 4, 5-triamine (1). The latter on reaction with Tri ethyl ortho formate in presence of acid form 6-chloro-9-(3-chloro-4-fluorophenyl)-9H-purin-2-amine (2).A new series of derivatives were synthesized from 6-chloro-9-(3-chloro-4-fluorophenyl)-9H-purin-2-amine. The structures of these analogues have been established by 1H NMR, IR and Mass spectral data. This study describes the anti-fungal activity of 6-chloro-9-(3-chloro-4-fluorophenyl)-9H-purin-2-amine analogues. The docking study results disclosed that few derivatives of 6-chloro-9-(3-chloro-4-fluorophenyl)-9H-purin-2-amine had outstanding anti-fungal activity which was superior to the activity of abacavir also.

Keywords: 6-chloro purine, ethanol amine, hydrazine hydrate,6-Alcoxy purines, benzyl amines, Anti-fungal activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia