EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

DEVELOPMENT AND CHARACTERIZATION OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF PANTOPRAZOLE

Piyush Kumar Dhiran, Gufran Ajmal*, Charu Bharti, Nasiruddin Ahmad Farooqui, Himanchal Sharma and Himanshu Kumar

ABSTRACT

Objective: In the current research pantoprazole loaded osmotically controlled release tablets were prepared utilizing a two-step process. Methods: Firstly, compression of tablets and second is coating of tablet by a semi-permeable membrane. Precompression parameters were performed like, tapped and bulk density along with angle of repose. Six formulations were prepared out of which one optimized formulation was selected, according to evaluation parameters like hardness, Friability, Content uniformity of drug and In vitro studies. Results: The hardness was revealed be in the limit as mention in Pharmacopoeias. The release of drug was found to be up to 8 hours. The tablets were also optimized for their effect of pH and agitation speed. Conclusion: The results concluded that the tablets have no significant effect for pH and agitation speed. Stability studies as ICH guidelines were performed, the results concluded that for 90 days the tablet shows stability and hence suitable for effective use.

Keywords: Pantoprazole, Osmotic Drug Delivery System, Peptic Ulcer, Dip Coating.

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