EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTS OF COMMONLY USED ANTIDEPRESSANTS ON PSYCHOMOTOR FUNCTIONS IN ADULT PATIENTS WITH DEPRESSION: A PROSPECTIVE OPEN LABEL OBSERVATIONAL STUDY

*Dr. Prashant Mishra

ABSTRACT

Context: Cognitive and psychomotor functions are impaired often in patients with depression and their further impairment by antidepressants is undesirable Data on effect of commonly prescribed antidepressants on psychomotor functions in patients with depression in the Indian context are limited. Aim: Study aimed to determine the effects of commonly prescribed antidepressants (Doxepin, Fluoxetine, Citalopram, Sertraline) on psychomotor functions in patients with depression. Materials and Methods: 100 participants [20 healthy volunteers and 80 with depression being treated with one of following daily medication: doxepin (75 mg) / Fluoxetine (20 mg) / Citalopram (20 mg) / Sertraline (50 mg) for 12 weeks] were put to various psychomotor function tests (DSST, SDCT, CFFT, SVL, HST, Trail A and B). Results were compared and analyzed. Statistical analysis used: Comparisons were made using one–way analysis of variance [ANOVA] for all psychomotor tests except CFFT (Kruskal Wallis Test used), followed by Bonferroni multiple comparison test. Results: The psychomotor tests were impaired most by fluoxetine [20 mg/day] and doxepin [75 mg/day], followed by citalopram [20 mg/day] and sertraline [50 mg/day] in comparison to control group. Conclusions: Psychomotor impairment is an important consideration while treating patients with depression; participants treated with sertraline suffer lesser impairment in psychomotor function in comparison to many of the other commonly prescribed SSRIs.

Keywords: Antidepressants, depression, psychomotor function.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )