EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

“INHIBITION OF CARBOHYDRATE DIGESTIVE ENZYMES BY SELECT PLANT EXTRACTS: ROLE IN THE MANAGEMENT OF DIABETES MELLITUS?”

Renuka Premal Munshi*, Falguni Hitesh Panchal, Dipika Haresh Shinde

ABSTRACT

In the present study, 5 Indian medicinal plants i.e. Azadirachta indica, Momordica charantia, Gymnema sylvestre, Syzygium cumini and Trigonella foenum graecum were screened for their in vitro α-amylase and α-glucosidase inhibitory activity. Aqueous, hydroalcoholic and alcoholic extracts of these plants were tested for qualitative phytochemical analysis using biochemical method. α- glucosidase and α- amylase inhibitory effect of the plant extracts was determined in-vitro using Elisa and spectrophotometric methods respectively. The phytochemicals analysis showed the presence of alkaloids, flavonoids, tannins, glycosides in all the plant extracts except for saponin which was seen only in Momordica charantia and Trigonella foenum graecum. Acarbose, a known inhibitor showed an IC50 value of 101.33μg/ml while the 3 different extracts of all the plants showed IC50 values ranging from 15.5 to 76.66μg/ml of α-glucosidase enzyme activity except for the alcoholic extract of Azadirachta indica whose IC50 value was higher than acarbose (214.66μg/ml). In case of α-amylase inhibitory activity, the IC50 of aqueous and hydroalcoholic extracts of Azadirachta indica & Momordica charantia, alcoholic and hydroalcoholic extracts of Gymnema sylvestre and aqueous and alcoholic extracts of Syzygium cumini showed IC50 value lower than the acarbose. Thus, amongst the 5 plants, Azadirachta indica, Momordica charantia, Gymnema sylvestre and Syzygium cumini exhibited potent inhibition of both α-glucosidase and α-amylase enzyme activity and thus may be considered for further studies to identify the active constituents responsible for this inhibitory activity followed by detailed in vivo studies to confirm these findings as per the drug development process to identify novel plant based drugs in the management of diabetes.

Keywords: Medicinal Plants, phytoconstituents, alpha amylase, alpha glucosidase, Diabetes mellitus.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )