FORMULATION AND DEVELOPMENT OF OSMOTIC CONTROLLED RELEASE TABLET BY PUSH PULL TECHNIQUE
D. Amulya*, Dr. P.V. Murali Krishna, Kolavali Yalla Reddy, J. Praveen Kumar and Dr. D. Venkata Narayana
The aim of the current study was to design a bilayer-core osmotic tablet which does not require laser drilling or mechanical drilling to form the drug delivery orifice instead of it water soluble pore forming agents were used in the coating solution to form a micro porous membrane. The bilayer-core consisted of two layers: (a) drug layer and (b) push layer, and sodium chloride was used as osmogent and polyox N-80 as a suspending agent in the push layer. Cellulose acetate was employed as semi permeable membrane containing polyethylene glycol 400 as a pore forming agent and also as a plasticizer to improve the film properties. It has been observed that the drug release rate increased with the amount of osmogent because of increased water uptake, and hence increased driving force for drug release. The drug release was inversely proportional to amount of polymer used in drug layer and the membrane weight gain; however, directly related to the level of pore former, in the membrane. The optimized formulation was subjected to stability studies as per International Conference on Harmonisation (ICH) guidelines and formulations were stable after a 3 month study.
Keywords: Osmotic tablet, Suspending agent, Plasticizer, Polymer, stability etc.
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