EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CINNAMALDEHYDE ANALOGUES: A NOVEL THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS

Aysha K. M.*, Thasneem C. K., Dr. Shijikumar P. S., Dr. Sirajudheen M. K. and Sherin A.

ABSTRACT

Cinnamaldehyde analogues are a class of chemical substances originated from derivatives of cinnamaldehyde, and are structurally characterized by the presence of cinnamoyl moiety. Cinnamaldehyde is obtained from cinnamon which consists of dried inner bark of the shoots of coppiced trees of cinnamomum zeylanicum of the family Lauraceae. They have diverse range of biological property such as flavourant, agrichemical, anti-microbial agent, anticancer agent, mild astringent, fungicide, anti- inflammatory etc. Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of joints which also cause inflammation of tissues around the joints as well as in the other organs in the body, which is responsible for the deformity and disability. Due to the presence of highly reactive α, α-unsaturated carbonyl pharmacophore in their structure, these molecules are apt to react with some enzymes and receptors as electrophiles. The naturally occurring molecules of this group such as transcinnamaldehyde and all have attracted lots of interest for their bioactivities especially for anti-inflammatory properties. This review summarises the progress of cinnamaldehyde analogue on anti-arthritic patients, illustrate its potent bioactivity, and discuss their potential as therapeutic agents.

Keywords: Cinnamaldehyde, Schiffs base, Phenylpropanoids, Anti-inflammatory, Rheumatoid Arthritis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )