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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Dr. Khaleel M. Ali Khan, Dr. Divyashree N.*, Dr. Geeta S. Narayanan and Dr. Bhanumathy G.


Background: The management of loco regional or locally advanced esophageal or gastro esophageal junction cancer has shifted from surgery or radiation single modality approaches to tri modality approach with the addition of chemotherapy.[1] This Multimodality approach can cause various treatment-related complications.[2-4] Despite improved local, regional, and distant control and increased survival, roughly 50% of patients treated with chemoradiation will have persistent local disease or recurrence.[5] Hence better local treatment through radiotherapy may be needed to improve the overall treatment outcome. Aims and objectives  To compare Planning Target Volume (PTV) coverage and doses to normal structures between 3DCRT and IMRT plans for esophageal carcinoma patients.  To evaluate if Dose Escalation is possible by using IMRT. Methods: A total of 30 patients presenting to department of Radiation Oncology with non-metastatic Carcinoma Esophagus of any subsite with less than or equal to 10 cms were enrolled to the study. Patients were treated with 3DCRT to a dose of 5040cGy in 28 fractions. Three IMRT plans were generated on the same CT images. First plan of dose 5040cGy was compared with 3DCRT plan for PTV coverage and doses to organs at risk using DVH. Two more plans were generated to check feasibility of dose escalation to 6040cGy and 7040cGy with respect to organs at risk. Results: In our study IMRT had a better PTV coverage and Conformality Index (CI) when compared with 3DCRT. Doses to normal structures like Spinal cord and Heart were significantly spared with IMRT (p < 0.001) while Lung doses were higher in IMRT. Dose escalation to 6040cGy and 7040cGy was feasible with IMRT as the organs at risk did not exceed tolerable limits. Interpretation & Conclusion: IMRT offers the opportunity to sculpture radiation dose by improving target homogeneity while sparing normal organs by taking advantage of a sharp dose gradient except lung. Hence Hybrid technique of combining 3DCRT and IMRT is recommended to take advantage of both the techniques.

Keywords: 3DCRT, IMRT, Carcinoma Esophagus.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database