LATEST ADVANCES IN MOUTH DISSOLVING FILM: A REVIEW

Dhanshri Bhaurao Sagle* and Komal Sanjay Mande

ABSTRACT

Mouth Dissolvable films (MDFs) evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers. MDF which disintegrate or dissolve within 1min when placed in the mouth without drinking water or chewing. Also, used for the taste masking of widely bitter tasted drugs which are most important for the paediatric patients. These drug delivery systems allow the medication to bypass the first pass metabolism thereby making the medication more bio available. Formulation of oral films involves the application of both aesthetic and performance characteristics such as plasticized hydrocolloids, active pharmaceutical ingredient, taste masking agent being laminated by solvent casting or hot melt extrusion. This review describes about the formulation methodology, evaluation parameter. Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided. These points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking. In the present review, recent advancements regarding fast dissolving buccal film formulation and their evaluation parameters are compiled.

Keywords: Mouth Dissolving Film, components, methods of preparation, Applications, evaluation, packaging of films.