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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Asim Awad Mohammed Ahmed*, Mohammed Elimam Ahamed Mohammed, Dafalla Omer Abuidris Elmustafa, Kanan Sanhouri, Ali Idris, Mohamed E. Abdelwadoud6, Abdelbasit M. I. Hussein, Dr. Hisham Altyb and Adil Abdelrahim Mohammed Yousif


Human papilloma viruses 16 and 18 (HPV-16 and HPV-18) are well known to play some roles in cervical and oral squamous cell carcinomas. The aim of this study was to investigate the expression of HPV-16 and HPV-18 in normal and cancerous oral squamous tissues using the immunohistochemistry (IHC) and polymerase chain reaction (PCR) techniques. Fifty one oral squamous carcinoma tissues and 49 normal oral squamous tissues were investigated for HPV-16 and HPV-18 detection. The immunohistochemistry results showed that the HPV-16 was positive in 2.04% of the normal tissues and in 9.8% of the cancerous tissues while the HPV-18 was positive in 8.2% and 17.6% of the normal and cancerous tissues, respectively. There was insignificant variation between the IHC results of the normal and cancerous tissues. 4.08% and 5.9% of the normal and cancerous tissues were positive for HPV-16 PCR, respectively. Concerning the PCR results of the HPV-18, all the normal and cancerous tissues were negative for HPV-18. There was insignificant variation between the HPV-16 detection by IHC and PCR while the HPV-18 detection by IHC was significantly sensitive compared to the PCR. The odd ratios of IHC for HPV-16 and HPV-18 showed that being positive was more likely to be OSCC 5.22 and 2.42 times, respectively compared to being negative for them. There was an insignificant variation between the expression of HPV-16 and HPV-18 in the normal and cancerous oral squamous tissues of the Sudanese subjects. The IHC was significantly sensitive for the detection of HPV-18 than the PCR.

Keywords: OSCC, IHC, PCR, HPV-16, HPV-18.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database