CORE COMPONENTS OF THE METABOLIC SYNDROME IN NONALCOHLIC FATTY LIVER DISEASE: A STUDY IN RAJSHAHI MEDICAL COLLEGE HOSPITAL, RAJSHAHI, BANGLADESH

Ahmed Masiha Jamil* and Rahnuma Shirin

ABSTRACT

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition that is characterised by excess deposition of fat in liver. This ranges from simple steatitis to steatohepatitis, cirrhosis and hepatocellular carcinoma. Hypertension, diabetes, obesity and dyslipidemia are predisposing factors of NAFLD. Objective: The present study was undertaken to explore whether METS and its individual components areassociated with NAFLD. Materials and Methods: This was a cross sectional descriptive study conducted in medicine department, Rajshahi medical college, Rajshahi, Bangladesh done from July-2016 to June-2017.51 diagnosed NAFLD subjects and 40 healthy controls were included. NAFLD wasdiagnosed by ultrasound and serum Cpeptide was measured by Immulite technique. Results: The NAFLD and control subjects were age and BMI- matched (age in years, p=0.380 and BMI inkg/m2, p=0.763). On logistic regression analysis, taking NAFLD as the dependent variable a significant association was found with low HDL (p<0.001), WHR, PSG and dyslipidemia (p=0.019, p=0.031, p=0.001 respectively). Conclusions: Nonalcohlic fatty liver disease (NAFLD) does not seem to be associated with METS in Bangladeshi population as defined by the 3 major criteria provided by IDF, ATP III and WHO. Various components of METS like central obesity, dyslipidemia, hypertension, and diabetes are associated with NAFLD. However, they do not seem to cluster in the manner as predicted by IDF, ATP III and WHO criteria.

Keywords: Nonalcohlic fatty liver disease (NAFLD), Metabolic Syndrome (METS), Insulin Resistance, ELISA.