EVALUATION OF CARDIOVASCULAR ACTIVITIES OF AN AYURVEDIC PREPARATION 'KHADIRARISHTA' IN RAT MODEL
Md. Musfaqur Rahman Sajjad, Md. Taimuzzaman Sharif, Kaniz Nahar Deepa, Kamrun Nahar, Most. Shammi Rahman, Md.Yeunus Mian, Nur Jaharat Lubna, Asma Rahman, Md. Zakir Sultan, Shaila Kabir, Abu Asad Chowdhury, Mohammad
In recent medical treatment for various diseases, traditional or
alternative medicines such as Ayurvedic drugs are getting importance
and reputation day by day because they have fewer side effects and
give necessary pharmacological actions. But prolonged and excess
usage may lead to harmful effects such as damage of the heart muscle
leading to various types of arrhythmia and coronary artery diseases.
―Khadirarishta‖, an Ayurvedic drug, is being traditionally used for
heart diseases along with jaundice, anemia and abdominal tremor. The electrocardiographical
(ECG) parameters were measured in rat model before and after administration of
Khadirarishta. It was observed that Khadirarishta at a dose of 800 mg/kg was safe but 1600
mg/kg and 3200 mg/kg produced abnormal activities in the heart.
Keywords: Khadirarishta, ECG, Heart disease, Rat model, Traditional medicines.
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