EVALUATION OF CARDIOVASCULAR ACTIVITIES OF AN AYURVEDIC PREPARATION 'KHADIRARISHTA' IN RAT MODEL

Md. Musfaqur Rahman Sajjad, Md. Taimuzzaman Sharif, Kaniz Nahar Deepa, Kamrun Nahar, Most. Shammi Rahman, Md.Yeunus Mian, Nur Jaharat Lubna, Asma Rahman, Md. Zakir Sultan, Shaila Kabir, Abu Asad Chowdhury, Mohammad
Shah Amran*

ABSTRACT

In recent medical treatment for various diseases, traditional or alternative medicines such as Ayurvedic drugs are getting importance and reputation day by day because they have fewer side effects and give necessary pharmacological actions. But prolonged and excess usage may lead to harmful effects such as damage of the heart muscle leading to various types of arrhythmia and coronary artery diseases. ―Khadirarishta‖, an Ayurvedic drug, is being traditionally used for heart diseases along with jaundice, anemia and abdominal tremor. The electrocardiographical (ECG) parameters were measured in rat model before and after administration of Khadirarishta. It was observed that Khadirarishta at a dose of 800 mg/kg was safe but 1600 mg/kg and 3200 mg/kg produced abnormal activities in the heart.

Keywords: Khadirarishta, ECG, Heart disease, Rat model, Traditional medicines.