ATORVASTATIN FATE STUDY IN WATER CONTAMINATED WITH QUALITY CONTROL REAGENTS IN THE PHARMACEUTICAL INDUSTRY. EFFECT OF UV LIGHT
Fateh Naitali* and Hafida Ghoualem
ABSTRACT
Releases from the pharmaceutical industry are increasingly being detected in aquatic matrices. Atorvastatin is an inhibitor of HMG Co-A reductase, an enzyme whose activity is early in the synthesis of cholesterol. The objective of this work is the study of the fate of atorvastatin in water polluted by chemical reagents during quality control in a laboratory of a pharmaceutical industry in the presence and in the absence of a UV light. The results of this study will be used later to predict the impact of the presence of atorvastatin in the receiving waters. The results of the HPLC analyzes show that there is a variety of interactions between the chemical reagents used and the atorvastatin.
Keywords: Pollution, pharmaceutical industry, drug, reagents, HPLC, UV.
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