EVALUATION OF ANTI-OBESITY EFFECT OF AQUEOUS EXTRACT OF SOLANUM INDICUM L. FRUITS ON HIGH FAT DIET-INDUCED OBESE RAT

Nadine Joissy Epoh, Olivette Laure Matafack Dongmo, Reine Audrey Mache, Phelix Bruno Telefo*,
Félicité Mbiapo Tchouanguep

ABSTRACT

Background: solanum indicum Linn is a solanaceae family found mainly in India as well as in tropical and subtropical African regions. Different parts (fruits, leaves, roots) of this plant are used by the traditional practitioners in the treatment of abdominal pain and worm infestation, pain and fever, inflammation, insomnia, urinary complications, cardiac weakness... the aim here is to investigate the anti-obesity effect of the aqueous extract of S. indicum fruits in high fat diet induce obese rats. Methods: During 16 weeks obesity was induce in rats by high fat diet. Then, animals were treated during 42 days with plant extract at the doses of 25, 50,100, 200 mg/kg and Orlistat at 5mg/kg. The effect of the treatment was evaluated on food intake, body weight, Lee index, biochemical parameters and atherogenic index. Then organ and fat weights were taken. Results: The oral administration of extract leads to a decrease in body weight, but most significant in females. We also observe a significant decrease in fat weight and food intake as well as the serum levels of triglycerides, total cholesterol, LDL-cholesterol, atherogenic and Lee index in the obese animals treated. Those treated with the doses of 50 and 100 mg/kg of body weight showed significant variations of these parameters compared to orlistat (standard drug). Conclusion: This results show that the aqueous extract of S. indicum fruits possess significant anti-obesity potential on high fat diet induce obese rat.

Keywords: Solanum indicum Linn, obesity, Lee index, Lipid profile, high-fat diet.