EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

LIMITATIONS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND THE UTILITY OF NATURAL PRODUCTS FOR ANTINOCICEPTIVE AND ANTIEXUDATIVE EFFECTS

*Ohadoma S. C., Akah P. A., Okolo C. E. Okoro E. P. and Michael H. U.

ABSTRACT

Nonsteroidal anti-inflammatory drugs (NSAIDs) express anti-inflammatory, analgesic and antipyretic effects, essentially by reversible inhibition of the rate-limiting enzyme-cyclooxygenase (COX), in the biosynthesis of prostaglandins. Among the dominant widely used medications globally are NSAIDs and are indicated for various forms of acute and chronic pain, rheumatoid arthritis, gout and pyrexia. Also some of them (aspirin for instance) are employed for prevention of secondary cardiovascular disorder due to mainly their ability to suppress platelet aggregation. Despite these applications, NSAIDs are known to present limitations in their untoward effects, hence researchers in recent times, have focused their efforts toward various chemical modifications of NSAIDs such as nitro-aspirin, des-methyl (DM)-sulindac, phosphatidylcholine (PC)-aspirin, pegylated phosphoribuprofen, dual COX/LOX inhibitors, Copper (II)/NSAIDs complexes; as well as natural product system of medicine for the discovery of agents that exert efficacy and potency with minimum adverse effects. This study reviewed the mechanisms of action, clinical applications, potential antitumor activity, interactions and limitations of NSAIDs as well as natural products with promising antinociceptive and anti-inflammatory (mainly anti-exudative) activities, utilizing the advantage of the frequent occurance of natural products as complexes of structurally related analogues to be exploited for good efficacy and safety in humans.

Keywords: NSAIDs, limitations, natural products, Chikadoma, antinociceptives, antiexudatives.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )