EVOLUTION AND ASSESSMENT OF OPHTHALMIC IN-SITU GEL CONTAINING AZITHROMYCIN

Rashmi B.*, Somashekhar C. N. and D. V. Gowda

ABSTRACT

The aim of present work is to formulate and evaluate the thermo sensitive drug delivery system of azithromycin for the treatment of conjunctivitis in the form of in situ gel to overcome problem associated with the conventional eye drops such as rapid precorneal elimination, poor bioavailability and nasolacrimal drainage. The thermo reversible ophthalmic in situ gel were prepared by cold method using pluronic f 127 as thermosensitve polymer, HPMC K100LV as viscosity enhancing agent, carbopol as gelling agent all the three polymers are used in different concentration in different proportions, macrolide antibiotic drug azithromycin and benzalkonium chloride is used as preservative. Prepared formulation were subject for several evaluation. The developed thermo reversible in situ gel shows the sustained drug releases profile and was found to be stable, nonirritant and also passes the sterility test.

Keywords: Azithromycin, thermo sensitive drug delivery system, pluronic f127, HPMC K15M, carbopol, In-situ gel.