EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

BIOPOLYMER FORM CESTRUM NOCTURNUM FLOWER: ISOLATION, CHARACTERIZATION AND ITS UTILIZATION IN PREPARATION OF PHENYTOIN LOADED BIO-NANOSUSPENSION

Sushant Kumar*, N. V. Satheesh Madhav, Anurag Verma and Kamla Pathak

ABSTRACT

The aim of this research was to formulate phenytoin loaded bio-nanosuspension for targeting to brain via ear using novel isolated biopolymer form Cestrum nocturnum flower. The significance of this research was to isolate the bio-polymer by using an economical and simple procedure. Bio-polymer was subjected for various physicochemical characterizations with spectral analysis like UV, FT-IR, mass and H-NMR, DSC was done. The phenytoin loaded bio-nanosuspension (PCN1-PCN8) were prepared by bath sonication method using isolated stabilizer cum retardant novel bio-polymer in different ratio. Various formulations were evaluated for different parameters like pH study, dispersibility study, entrapment efficacy, zeta particle size, zeta potential, In-vitro release study, stability studies and In-Vivo study. The formulation PCN8 was found to be the best formulation having t50% of 17.06 hours and t80% of 29.06 hours with r2 value of 0.9899. The best formulation PCN8 showed up to 90.87% drug release over 36 hours. According to the release kinetic study the best fit model was found to be Korsmeyer Peppas and the mechanism of drug release was found to be Anomalous transport. The isolated biopolymer was found to have a promising, novel inbuilt stabilizer cum retardant polymeric properties for developing stable phenytoin loaded bionanosuspension. The formulated bionanosuspension was found to be safe and compatible for targeting to brain via ear.

Keywords: Biopolymer, Bio-nanoparticles, bionanosuspension, Phenytoin, Nanosizing, drug targeting.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing