EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CAFFEINATED ENERGY DRINK INDUCES OXIDATIVE STRESS, LIPID PEROXIDATION AND MILD DISTORTION OF CELLS IN THE RENAL CORTEX OF ADULT WISTAR RATS

Memudu, Adejoke Elizabeth*, Olarenwaju Ebun, Osahon, Itohan Roli and Oviosun, Augustine

ABSTRACT

Over the years, there has been an alarming increase in the production of different brands of caffeinated energy drink (ED) with different flavours that attracts the consumers with the aim of providing energy boost in their day to day activities. This study was conducted to effect of low and high doses ED on the renal histology system. Twenty-five adult male Wistar rats weighing 150-200 g were divided into five (5) experimental groups; Groups A: control, B treated with 2 ml ED, C treated with 2 ml energy drink and discontinued for 7 days, D treated with 4 ml ED, and E was treated with 4 ml energy drink and discontinued for 7 days. Histological analysis using haematoxylin and eosin, and PAS was conducted to ascertain the histoarchitectural integrity of the renal tissue. It was deduced from the study that caffeinated ED caused a significant increase in serum superoxide dismutase (SOD) level as compared with the control while MDA (malondialdehyde) serum activity increased as compared with control and withdrawal groups; increased in Bowman’s space, space, decreases the inner epithelial layer of the glomerulus as well as the epithelium of the proximal convoluted tubule. It was shown that ED consumption for a long time could affect the kidney by inducing oxidative stress and altering the histoarchitecture of the renal tissue. However, discontinuation of ED for 7 days shows positive potential of restoring the integrity of the renal cortex.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing