TO DESIGN EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF GLICLAZIDE
Apeksha V. Masal*, Nilesh A. Nalawade, Sagar D. Shinde, Swati B. Kavade and LoKesh K. Patil
Self emulsifying drug delivery system was developed to assess the oral absorption and to improve the oral bioavailability of Gliclazide. The SEDD is converted in to its S-SEDDS. For screening purpose the solubility of drug in to oil, surfactant, co-surfactanat was determined on the basis of that select suitable ingredients. The self micro-emulsion region was decided by constructing ternary phase diagram. The drug excipient interaction was study by using FTIR. From all screening four formulation variables were selected. Four formulation are prepared and evaluated parameter included visual assessment, self emulsification ,particle size , zeta potential and in vitro-dissolution was carried in USP apparatus II using 0.1N HCL buffer at 37±0.5˚ with 50 rpm rotating speed and drug release measured by UV Spectrophtometeric method. Result F1 oleic acid 10% (oil), 90% Tween20:n-butanol 2:1 ration. Optimized formulation F1 of SEDDS was observed with smaller size and zeta potential. Formulation was clear after the dilution with water. SEDDS formulation converted in to S-SEDDS by adsorption method using Aerosil 200 showed good flow properties. the S- SEDDS of Gliclazide showed drug release 96 % in 90 min as compared with pure drug Gliclazide. From the result of obtained screening SEDDS of Gliclazide could be promising to improve oral admistration of Gliclazide.
Keywords: Gliclazide, Microemulsion, Drug.
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