EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

TO DESIGN EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF GLICLAZIDE

Apeksha V. Masal*, Nilesh A. Nalawade, Sagar D. Shinde, Swati B. Kavade and LoKesh K. Patil

ABSTRACT

Self emulsifying drug delivery system was developed to assess the oral absorption and to improve the oral bioavailability of Gliclazide. The SEDD is converted in to its S-SEDDS. For screening purpose the solubility of drug in to oil, surfactant, co-surfactanat was determined on the basis of that select suitable ingredients. The self micro-emulsion region was decided by constructing ternary phase diagram. The drug excipient interaction was study by using FTIR. From all screening four formulation variables were selected. Four formulation are prepared and evaluated parameter included visual assessment, self emulsification ,particle size , zeta potential and in vitro-dissolution was carried in USP apparatus II using 0.1N HCL buffer at 37±0.5˚ with 50 rpm rotating speed and drug release measured by UV Spectrophtometeric method. Result F1 oleic acid 10% (oil), 90% Tween20:n-butanol 2:1 ration. Optimized formulation F1 of SEDDS was observed with smaller size and zeta potential. Formulation was clear after the dilution with water. SEDDS formulation converted in to S-SEDDS by adsorption method using Aerosil 200 showed good flow properties. the S- SEDDS of Gliclazide showed drug release 96 % in 90 min as compared with pure drug Gliclazide. From the result of obtained screening SEDDS of Gliclazide could be promising to improve oral admistration of Gliclazide.

Keywords: Gliclazide, Microemulsion, Drug.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing