EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT AND CHARACTERIZATION OF ORAL DISINTEGRATING MINI -TABLET CONTAINING SALBUTAMOL SULPHATE BY SUBLIMATION METHOD

Sanjana S.* and Somashekhar C. N.

ABSTRACT

In pharmaceutical industry oral drug delivery is presently regarded as the most accepted route. But the main drawback of the oral dosage forms like delayed on set of action, difficulty in swallowing and poor patient compliance. The aim of the present investigation was to develop and evaluate the oral disintegrating mini-tablet (ODMT) of Salbutamol sulphate by sublimation method for the treatment of Asthma and Chronic pulmonary diseases (COPD). Immediate release tablets are highly accepted because rapid release drug delivery systems and thus, an attempt was made to improve the lag time, bioavailability and patience compliance. To reach this goal three different superdisintegrants were used namely Crospovidone, Sodium starch glycolate, and Croscarmellose Sodium used in different concentration (3 and 9%). Along with camphor used as a sublimating agent. Miromeritic properties of the powder blend were well within the limit confirmed by having good flow property and FTIR and DSC studies confirm the compatibility between drug and excipients and post formulation parameters were evaluated. Among the formulations F2 resulted a least disintegration and dissolution studies hence concluded that ODMTs give better effect to the asthma and COPD patients to improve the lag time, better patient compliance.

Keywords: Oral disintegrating tablets, Salbutamol sulphate, Superdisintegrants, Sublimation method.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing