EVALUATION OF CARDIOVASCULAR RISK FACTORS IN PATIENTS OF SUBCLINICAL HYPOTHYROIDISM

Obaid M.*, Ashraf M. and Majid S.

ABSTRACT

Background and objectives: The association between thyroid disorders and cardiovascular disease is an active subject of research. While a no. of studies have been done on hypothyroid patients, subclinical hypothyroidism (ScH) is less researched. Mixed results have been reported in studies linking ScH with dyslipidemias, hypertension and anthropometric parameters. Data on Indian populations is relatively scanty. The current study was planned to evaluate the relationship of cardiovascular risk factors with ScH in Kashmiri population. Materials and Methods: A cross sectional study was conducted in the departments of Biochemistry and General Medicine, Govt. Medical College Hospital, Srinagar on fifty known patients of ScH and fifty age and gender matched euthyroid controls. Clinical and anthropometric details were collected. Thyroid hormones, lipid profile and blood glucose levels were estimated. Results and conclusions: Serum levels of fasting blood glucose, triglyceride, High density lipoprotein, and Low Density Lipoprotein in ScH patients were 99.02 ± 28.90 mg/dl, 166.32 ± 70.50 mg/dl, 43.82 ± 11.44 mg/dl, 111.58 ± 95.14 mg/dl respectively). The same were not statistically significant (P>.05). ScH patients had a systolic blood pressure of 118 ± 12.94 mmHg and diastolic blood pressure of 73.4 ± 7.45 mmHg as compared to 118.2 ± 13.04 mmHg and 74.2 ± 8.10 mmHg respectively in euthyroid controls. The same again were not statistically significant (p>0.05). Waist circumference and Body mass index were comparable. Thus in our study we did not find any association of cardiovascular risk factors with ScH.

Keywords: Hypothyroidism, Metabolic Syndrome, Obesity, Hypertension.