EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ACUTE ORAL TOXICITY AND ANTI TUSSIVE EFFECT OF MUKOSAN SYRUP (POLY HERBAL FORMULATION) ON SO2 INDUCED COUGH MODEL.

Nilesh Patel, Dr. Janmejay Patel, Achal Patel and Dr. Ankitkumar M. Paneliya*

ABSTRACT

Introduction: The various serious conditions of respiratory system like pneumonia, asthma, pulmonary HT and TB have one common cardinal symptom i.e. Coughing. The currently available various allopathic drugs like anti-tussive, expectorants, mucolytics etc., are being used for the treatment of cough which gives symptomatic relief in the most extents. But the involvement of debilitating side effects is major drawback of these drugs. Therefore, it is a unmet need to develop safe and effective antitussive therapeutic option for treatment of persistent cough as alternative to existing medicine. Aim: To evaluate Mukosan Syrup (poly herbal formulation) for acute oral toxicity in mice and antitussive effect in So2 induced cough model. Method: The present study was certified by IAEC (SKPCPER/IAEC/2016-02/02) as per the CPCSEA. The OECD guideline AOT-425 was followed during assessment of acute oral toxicity of test drug to know single dose toxicity. The selected animals were subjected to randomization with irrespective of their gender. A limit single dose (2000 mg/kg) of test drug was given to each mouse at 48 h intervals and observed periodically for 14 days for any clinical sign of toxicity or mortality. The modified and simplified method describe by Miyagoshi et al., 1986 was adopted for evaluation of antitussive effect in SO2 induced cough model in mice. Results: There were neither any physical - behavioral changes nor mortality observed in any animal during study period. The test drug showed significant decrease in cough bouts in compression to standard drug treated (codeine sulphate) group. Conclusion: The No-Observed-Adverse-Effect-Level (NOAEL) of Mukosan Syrup is 2000 mg/kg as it did not produce any toxicity at this dose. The significant decrease in cough bouts favors potential antitussive effect of Mukosan Syrup.

Keywords: Anti tussive, Acute oral toxicity, Mukosan Syrup, Mortality, NOAEL.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing