EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NANOEMULSION-BASED GEL FORMULATION OF LAMIVUDINE FOR TRANSDERMAL DELIVERY

Sushmitha A.* and Parthiban S.

ABSTRACT

Lamivudine is a anti-viral drug. The main purpose of the study is to develop nanoemulgel formulalation for transdermal delivery of Lamivudine using aloeveragel. The nanoemulsion can be prepared by using olive oil as oil phase and Tween-80 as surfactant and PEG 400 as co-surfactant were used in different ratio to determined by pseudoternary phase diagram. Four nanoemulsion were developed and coded as ON1, ON2, ON3, ON4 and the optimized formulation ON4 was converted into correponding gel by using Aloevera gel. The Lamivudine loded nanoemulsion were characterized by drug entrapment efficiency, pH, viscocity, transmittance and drug release, stability studies. Further, nanoemulgel formulation were evaluated by drug entrapment efficiency, pH, viscosity, drug release, stability studies. The nanoemulgel showed better release control and used for transdermal delivery of Lamivudine.

Keywords: Nanoemulgel, Lamivudine, transdermal delivery sytem.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing