EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF COCCINIA INDICA LEAF EXTRACT ON DIABETIC NEUROPATHY PAIN IN RATS

Ravikant*, Abhay Kumar Verma, Priyanka Shrivastava

ABSTRACT

We investigated the effect of freshly prepared alcoholic extract of coccinia indica leaves extract on neuropathic pain, blood glucose level and loss of body weight in hyperglycaemic rats. Streptozotocin (STZ; 60 mg/kg, IP) was injected to albino rats to induce diabetes. Oral administration of freshly prepared alcoholic extracts to each of the animal was given to STZ-induced diabetic rat until 7 weeks after the STZ injection at a dosage of 500 mg/kg/day and 250 mg/kg/day. The glucose level test to follow the changes in blood glucose and body weight measurement to evaluate loss of body weight in diabetic rats. The pain evaluated by stimuli thermal: warm immersion (52 +2 0C) and cold immersion test (10 0C) and paw withdrawal on Eddy’s hot plate (45-52 + 2 0C) in diabetic rats. Treatment with these freshly prepared leaf alcoholic extract significantly reduced blood glucose and pain in diabetic rats. Blood glucose lowering effect and analgesic activity of coccinia indica decreased the pain in STZ- diabetic rats. STZ-induced loss of body weight was attenuated by the alcoholic extract of the coccinia indica. The higher dose (500 mg/kg/day) of alcoholic extract of the coccinia indica works better than that of lower dose (250 mg/kg/day) against hyperglycaemia and painful neutopathy. Therefore the use of these plants as analgesic and antidiabetic is justified. Glibenclamide (10 mg/kg/day) is an antidiabetic drug used as a standard drug to maintain the glucose level and diabetic neuropathic pain in diabetic rats.

Keywords: Coccinia indica, Neuropathic pain, Streptozotocin (STZ), Glibenclamide, Hyperglyceamia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )