ETIOLOGY OF CANCER: A DEADLY OCEAN
S. Akila* and R. Deepti
Abnormal proliferation of cells that grow beyond its usual boundaries is termed as cancer. Cancer invades adjacent parts of the body and spreads to other organs. World Health Organisation (WHO) has stated that globally near 1 in 6 death is due to cancer. Major cause of this deadly disease are potential risk factors (aging, family history and obesity), environmental agents (chemical, radiation and microorganisms) and mutated genes (tumor suppressor genes, Proto oncogene, DNA repair gene and telomere). Increased secretion of estrogens, leptin and decreased levels of adiponectin can contribute to tumorigenesis. Among all these factors, 22% of cancer death is only due to tobacco. Environmental agents and potential risk factors can cause initiation of cancer by either activating or suppressing the genes.
Keywords: Proto oncogene, adiponectin, tumorigenesis and leptin.
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