CHARACTERIZATION OF NEW METHYLATION MARKERS AND THE EXPRESSION OF GENES INVOLVED IN CARCINOGENESIS IN BREAST CANCER
*Alimkhodzhaeva L.T., Zakirova L.T., Nigmanova N.A. and Shamansurova N.S.
Modern oncology considers the RARβ2 gene as an important link in the pathogenesis of breast cancer and is being investigated as a new potential biomarker for breast cancer, in particular, a prognosis marker, tumor response to therapy, and metastasis. Point mutations of this gene are rare, but hypermethylation is observed in approximately 15% of breast cancer cases.
The aim of this work was to evaluate RARβ2 hypermethylation in breast cancer and explain it from a biological point of view.
Keywords: breast cancer, RAR?2, breast cancer biomarker, hypermethylation.
[Full Text Article]