( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Sujith S. Nair, Roopitha Padmanabhan and Sreena K.


The main aim of the work is to develop a novel, fast dissolving product on the technology platform of a small and thin drug loaded film called oral thin films or oral wafers for achieving faster disintegration and dissolution with improved bioavailability. Prochlorperazine maleate which is a phenothiazine antipsychotic is used as the model drug for the development of oral thin films. It is used in the prevention and treatment of nausea, vomiting associated with migraine (or severe head ache) or drug induced emesis. Fast dissolving oral thin films from Prochlorperazine maleate were formulated by solvent casting method by using HPMC E15 as film forming polymer, glycerol and propylene glycol as plasticizers, tween 80 as surfactant, mannitol as sweetening agent, citric acid as saliva stimulating agent and sodium starch glycolate as superdisintegrating agent. The prepared films were then evaluated for physical appearance test, surface pH, thickness, weight variation, tensile strength, content uniformity, in vitro disintegration test and in vitro dissolution test. From the evaluation studies, all the films were found to show satisfactory results. The film F7 containing 200 mg of HPMC E15, 0.5 ml of tween 80, 0.6 ml of glycerol and 0.8 ml of PEG 400 was found to show more release of drug i.e. 99.23 % at the end of 16 minutes was selected as the best formulation. To the best formulation F7 5% of sodium starch glycolate was added and evaluated. The film was found to disintegrate in 25.67±0.5774 seconds and released 94.59 % of drug at the end of 10 minutes. The kinetics studies indicated that the film showed zero order with Korsmeyer – Peppas plot indicating non- fickian diffusion.

Keywords: Oral thin films, Prochlorperazine maleate, Non-fickian diffusion, Fast dissolving.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )