EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DESIGN AND SYNTHESIS OF BIOGENIC SILVER NANOPARTICLES FROM AQUEOUS LEAF EXTRACT OF MIRABLIS JALAPA L., AND EXPLORING IT’S INVITRO ANTI-CANCER ACTIVITY

M. Sangeetha* and C. Mahendran

ABSTRACT

In recent science Nanotechnology is a burning field for the researchers. Nanotechnology deals with the Nanoparticles having a size of 1 – 100 nm in one dimension used significantly concerning medicinal chemistry, atomic physics, and all other known fields. Mirablis Jalapa L(Family: Nyctaginaceae) is versatile medicinal plants enriched with novel bioactive molecules and displays board-spectrum pharmacological actions including anticancer potential. The study planned to biosynthesize anticancer potent silver nanoparticles using aqueous leaf extract of Mirablis Jalapa. The synthesized nanoparticles were confirmed by colour transformation and UV-Vis spectrophotometry. The size and morphology of the silver nanoparticle were characterized by Scanning electron microscope (SEM). The stability of silver nanoparticles were detected by Fourier Transform Infra Red Spectroscopy (FT-IR). EDAX and Zeta potential were also detected for silver nanoparticles. Anticancer activity of silver nanoparticles tested against Dalton’s Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma(EAC) cells. The appearance of reddish brown colour and UV absorption 428 nm (OD=0.0695) confirmed the synthesized silver nanoparticles. The silver nanoparticles showed spherical structure and their size were ranging from 1- 100 nm under SEM observations. FT-IR spctra of silver nanoparticles showed the peaks for the functional groups, C=O,-C=C,C-H and OH which indicate the stability of synthesized silver nanoparticles. The synthesized of silver nanoparticles using aqueous extract of leaves of Mirablis Jalapa would be helpful for the preparation of potent cytotoxic agents against DLA and EAC cells to destroy cancer cells.

Keywords: Mirablis Jalapa, Green synthesis, Silver nano particles, EDAX, Anti cancer activity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing