EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIMICROBIAL ACTIVITY OF DIFFERENT EXTRACTS OF SIDDHA DRUG ATTATHI CHOORANAM (ATC)

Rasenthiran Sasvatha* and Manoharan A.

ABSTRACT

Attathi chooranam (ATC) is a classical Siddha herbo-mineral drug. The aim of this research was to find out the antibacterial activity of ATC against the five gram-positive, five gram-negative bacteria and anti-fungal activity of five fungi in different extracts. The ethanol extracts of 50 ℓ and 100 ℓ of ATC showed the highest antimicrobial activity against all the positive and negative tested bacteria and fungi when compared to aqueous extracts. 100 ℓ of ethanol extract of ATC has high activity against gram-positive and gram-negative bacteria and fungi than 50 ℓ of ethanol extract. The highest anti-bacterial activity recorded 100 ℓ and 50 ℓ of ethanol in gram-negative bacteria Klebsilla pneumonia (25 mm & 22 mm), Pseudomonas aeruginosa (26 mm &18 mm) and gram-positive bacteria Staphylococcus aureus (24 mm & 16 mm), Streptococcus mutans (22 mm & 20 mm) which were compared with positive control of Streptomycin. All extracts of ATC have high activity against gram negative bacteria compared with gram positive bacteria. ATC extracts of 100 ℓ and 50 ℓ of ethanol exhibited potential antifungal activity against Aspergillus niger (18 mm & 14 mm) compared with positive control (fluconazole). According the 100 ℓ and 50 ℓ of aqueous extracts of ATC kept antifungal activity against Penicillium notatum (18mm & 15 mm) and Candida Albicans (15 mm & 11 mm) meanwhile activity has not been reported against Aspergillus flavus, Aspergillus niger and Rhizopus stolonifera.

Keywords: Anti-bacterial activity, Anti-fungal activity, Attathi chooranam, Disc diffusion method.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing