EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF AN ANTI-DIABETIC DRUG

Sagar D. Shinde*, Nilesh A. Nalawade, Swati B. Kavade and Apeksha V. Masal

ABSTRACT

Saxagliptine has a relatively short elimination half-life (2.5 h), thereby requiring twice or thrice daily dosing in patients, which may lead to non-compliance. Extended release formulation of Saxagliptine based on osmotic technology was developed and evaluated. Controlled Porosity osmotic tablets of Saxagliptine were developed using Self Pore forming agent Mannitol. Prepared tablets were evaluated for their Flow property, weight variation, hardness, friability and content uniformity. Tablets were coated with a semi permeable membrane using 6% w/v cellulose acetate Phthalate (CAP) in isopropyl alcohol and Methylene chloride and Polyethylene Glycol-400 as plasticizer. Drug release rate was increased as the increase of Mannitol amount in Core Tablet. Drug release was inversely proportional to weight gain but directly proportional to the Self pore forming agent. The drug release from developed formulations was independent of pH and agitation intensity of release media. The DSC and FTIR studies demonstrated that there was no interaction between polymers and drug. The optimized formulation was stable after one months of accelerated stability studies.

Keywords: “Saxagliptine, “Extended release", Osmotic technology.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing