( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Dr. Talat Farheen*, P. Srikanth, Suddala Anusha, Dwivedi Kanchan and Dr. Nijhawan Monika


The present investigation concerns the development of a new oral drug delivery system utilizing the concepts of controlled release and mucoadhesion, which would remain in stomach and extend the drug release for longer period of time. Levofloxacin is used to treat a variety of bacterial infections. It belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria. Levofloxacin mucoadhesive microspheres were prepared by solvent evaporation technique using carbopol 934P and hydroxypropyl methyl cellulose K4M (HPMC K4M). The prepared microspheres were subjected to evaluation of particle size, entrapment efficiency, drug content, in vitro wash off test and in vitro drug release studies. Absence of drug-polymers interaction was confirmed by fourier transform infrared spectrophotometry. The particle sizes of batches ranged between 304.5 μm to 456.6 μm. The drug entrapment of formulations was about 70 to 88.3%. The prepared microspheres showed a strong mucoadhesive property i.e., 79.3% to 91.1%. The polymer concentration influenced the in vitro drug release significantly in 0.1N HCl which suggested sustained drug release from formulations and was found to be in the range of 78.9 to 87.4%. The prepared factorial batches have shown a nearly spherical shape with rough surface. F7 factorial batch was selected as optimized batch because it has shown maximum mucoadhesion and sustained the release of drug from formulation up to 8 hours. Regression analysis revealed that the drug release from the optimized batch followed zero order kinetics. From the above results, it was concluded that the mucoadhesive microspheres of levofloxacin has feasibility for eradicating Helicobacter pylori from the stomach more effectively because of the prolonged gastrointestinal residence time and controlled release of drug from the formulation.

Keywords: Levofloxacin, carbopol 934P, hydroxypropyl methyl cellulose K4M, Helicobacter pylori, mucoadhesion.

[Full Text Article]



  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )