MESENCHYMAL STEM CELLS OBTAINED FROM THE HUMAN UMBILICAL CORD HAVING CAPACITY TO TREATS AILMENTS: A REVIEW

Gaurav M. Prajapati*, Ranajit S. Kadam and Dipak B. Khillare

ABSTRACT

The human umbilical cord, a tissue connecting the embryo to the uterus of the mother. Early researchers showcase that the embedded stromal cells were not the only in charge of the Synthesis of matrix components and expansion of the cord, but also for the intercellular communication and constriction. Adult stem cells (ASCs) which can be easily obtained from various tissues, such as the skin, bone marrow, and adipose can be used further to treat disorders of vital bodily organs with less concern than ESCs. Research and different regenerative medicines, which include medicines treating Parkinson's disease, intracerebral hemorrhage, liver disease, brain disease, etc. Different stem cells have been studied to find an effective treatment for this incurable disease. MSCs have an anti-inflammatory effect which reduces the damages in the hepatocytes. The huc-MSCs migrated to the ischemic bounded area, got divided into glial, neuronal, doublecortin, CXCR4+, and the vascular endothelial cells. Also, huc-MSCs thus implanted supported the formation of new vessels to increase the flow of blood, and increase in expression of neuro-tropic factors.

Keywords: Human umbilical cord, intracerebral hemorrhage, brain diseases, MSCs, anti-inflammatory effect, neuro-tropic factors.