An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Kushal Nandi and Dr. Dhrubo Jyoti Sen*


Pain is unwanted symptom of body malfunction which is not desired by anyone. It is of two types: superficial & neurogenic. Pain is generated by three biogenic precursors: prostaglandins, thromboxanes and leukotrienes. All three are C-20 carbon units having free carboxylic acid units which stimulate cyclooxygenase enzymatic pathway to produce sensation of pain. Feeling of pain is at nerve endings as superficial and generation from spinal cord to produce neurogenic pain. Pain produce inflammation which accumululate body fluids at a particular segment produce swelling and redness due to discharge of histamines to feel the sensation of pain. Pain can be controlled by two types of analgesic drugs: opioids and non-opioids. Generally morphine derivatives come in opioid analgesic and salicylates come under NSAIDs as non-opioids. Analgesic agents block arachidonic acid pathway by blocking phospholipase A2 to block the further process in prostaglandin synthase, lipoxygenase and thromboxane synthase pathways to block the biosynthesis of COX1 & COX2 isozymes, LTAs & TXA and TXB.

Keywords: Pain, Allodynia Pain, Phantom Pain, Asymbolia Pain, Idiopathic Pain, Nociceptive Pain, Neuropathic Pain, Visceral Pain, Nociplastic Pain, Pain Precursors, Eicosanoids, Arachidonic acid, Prostaglandin, Thromboxane, Leukotriene.

[Full Text Article]



  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing