EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARTIVE REVIEW OF OPTHALMIC IN SITU GEL

Aseem Bhateja*, Nishant Thakur and Manish Goswami

ABSTRACT

The poor bioavailability of typical ophthalmic formulations is because of fast precorneal drug loss (through dilution and voidance from the eye). There square measure some static (different layers of the attention i. e. cornea, sclera, retina) and dynamic barriers (blood liquid and blood retinal barrier) that conjointly have an effect on the bioavailability of drug. the matter are often overcome by victimization in place forming ophthalmic drug delivery system ready from compound that exhibit reversible liquid–gel natural process. in place gels square measure the liquid preparations that upon instillation undergoes natural process in cul-de-sac of the attention to create a viscous gel and this happens because of the environmental changes within the eye (i.e. because of amendment in temperature, amendment in particle concentration} and ion evoked change). This novel drug delivery system promotes the significantly ease and convenience of administration, rescue of correct dose still on prolong duration of drug to bear with membrane. The first demand of a eminent management unleash product focuses on increasing patient compliance, sensible stability and biocompatibility characteristics that create the in place gel indefinite quantity forms terribly reliable. This review is to specify the fundamental anatomy and physiology of human eye, varied approaches used for formulation of unmoved gels and polymers utilized in the formulation of in place gels.

Keywords: In situ gel, in situ gelling polymers, pH sensitive, temperature sensitive, ion sensitive.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing