COMPARTIVE REVIEW OF OPTHALMIC IN SITU GEL
Aseem Bhateja*, Nishant Thakur and Manish Goswami
The poor bioavailability of typical ophthalmic formulations is because of fast precorneal drug loss (through dilution and voidance from the eye). There square measure some static (different layers of the attention i. e. cornea, sclera, retina) and dynamic barriers (blood liquid and blood retinal barrier) that conjointly have an effect on the bioavailability of drug. the matter are often overcome by victimization in place forming ophthalmic drug delivery system ready from compound that exhibit reversible liquid–gel natural process. in place gels square measure the liquid preparations that upon instillation undergoes natural process in cul-de-sac of the attention to create a viscous gel and this happens because of the environmental changes within the eye (i.e. because of amendment in temperature, amendment in particle concentration} and ion evoked change). This novel drug delivery system promotes the significantly ease and convenience of administration, rescue of correct dose still on prolong duration of drug to bear with membrane. The first demand of a eminent management unleash product focuses on increasing patient compliance, sensible stability and biocompatibility characteristics that create the in place gel indefinite quantity forms terribly reliable. This review is to specify the fundamental anatomy and physiology of human eye, varied approaches used for formulation of unmoved gels and polymers utilized in the formulation of in place gels.
Keywords: In situ gel, in situ gelling polymers, pH sensitive, temperature sensitive, ion sensitive.
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